neoformans in Mind microvascular endothelial cells (BMECs) involves protein kinase C-alpha activation. The CPS1 gene is required for C. neoformans adherence into the surface area protein CD44 of human BMECs [fifteen]. The dissemination of pathogen in the brain is managed by Isc1 gene encoding an enzyme that hydrolyzes inositol. Lately, Huang et al.